Experiments in virology - Étienne Decroly - Éditions Quae

Experiments in virology

Benefits and risks

by Étienne Decroly (author)
Collection: Sciences en questions
june 2025
Open Access
Expériences en virologie - Expériences en virologie - eBook [ePub] [ePub]
Expériences en virologie - eBook [PDF]
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Summary

Research in virology is a major societal challenge in addressing the emergence of new pathogens. Recent advances in synthetic biology have made it possible to modify viral genomes quickly and efficiently, facilitating the development of “humanized“ animal models, essential for studying infections and designing more effective vaccines. However, this research raises important questions regarding risk management and biosafety, as viruses can pose a threat to global public health.
Despite safety standards implemented to protect researchers and society, research accidents have occurred. Zero risk does not exist. This book addresses ethical and practical questions surrounding such research, in particular the controversial “gain-of-function“ experiments on viruses with pandemic potential. 
The author questions the need of such experiments to anticipate the emergence of new pathogens, and advocates for stricter regulation in the field of virology research to better protect society while continuing to make progress in the fight against viral diseases.

Table of contents

Foreword

Introduction

The challenges of virology research in the field of public health

Some examples of pandemics

The fight against viruses: vaccines and antivirals

Virology research: a continuum of risk

The nature of laboratory experiments

Virus in tissue culture

Cloning of viral genomes

Animal models

Gain-of-function experiments

Understanding the challenges of gain-of-function experiments

Pathogens with pandemic potential

Biosafety levels

Adapting biosafety constraints to biological risks

Laboratory accidents are not exceptional

Which experiments for which risks?

Serial passage experiments
Identification of escape variants
Experiments on animal models
Synthetic biology in virology
Gain-of-function experiments on influenza viruses are particularly risky
Equally problematic risks for gain-of-function experiments on coronaviruses
Gene deletion can sometimes increase viral pathogenesis

Alternatives to gain-of-function experiments exist

How can high-risk experiments be regulated and better controlled?

Conclusion

Discussion

Bibliography

Les crises sanitaires environnementales

Livre papier19 €

Les virus

Livre papier16 €

Émergence de maladies infectieuses

Livre papier19 €

Les zoonoses

Livre papier16 €

Sortir des crises

Livre papier35 €

Quelles alternatives en expérimentation animale ?

Livre papier29 €

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Features

Language(s): French

Publisher: Éditions Quae

Edition: 1st edition

Collection: Sciences en questions

Published: 19 june 2025

EAN13 Expériences en virologie - eBook [ePub] [ePub]: 9782759240555

EAN13 eBook [PDF]: 9782759240548

DOI eBook [PDF] : 10.35690/978-2-7592-4054-8

Pages count Expériences en virologie - eBook [ePub] [ePub]: 70

Pages count eBook [PDF]: 70

Interior: Black & white

Reference Expériences en virologie - eBook [ePub] [ePub]: 02999EPB

Reference eBook [PDF]: 02999NUM

Size: 341 KB (ePub), 822 KB (PDF)

Onix format
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